Table 1.
Characteristics of total MHD patients, MHD patients with and without diabetes
| Characteristic | Total(N = 62) | With diabetes(N = 27) | Without diabetes(N = 35) | P |
|---|---|---|---|---|
| Male(0)/female(1) | 30/32 | 14/13 | 16/19 | 0.798 |
| Age (year) | 58.10 ± 15.98 | 65.33 ± 13.17 | 52.51 ± 15.87 | 0.001 |
| Smoking, (%) | 21.0 | 25.9 | 17.1 | 0.297 |
| Vintage (months) | 29.27(8.65, 78.02) | 19.28(3.78, 52.50) | 40.27(16.16, 98.00) | 0.007 |
| Residual urine volume (ml/24 h) | 0(0, 200) | 100(0, 400) | 0(0, 150) | 0.123 |
| SBP (mmHg) | 155.05 ± 21.53 | 163.37 ± 17.68 | 148.63 ± 22.24 | 0.005 |
| DBP (mmHg) | 79.03 ± 16.13 | 68.48 ± 11.92 | 87.17 ± 14.32 | < 0.001 |
| Comorbid CHD, (%) | 30.6 | 40.7 | 22.9 | 0.108 |
| NGAL (ng/mL) | 52.02(43.11, 422.30) | 49.33(42.37,55.48) | 56.78(44.37,674.13) | 0.026 |
| Klotho (pg/mL) | 308.49(76.94, 877.32) | 265.22(11.70, 1391.19) | 319.96(138.46,608.23) | 0.836 |
| Ca (mmol/L) | 2.29(2.17, 2.41) | 2.21(2.12, 2.32) | 2.35(2.27, 2.51) | 0.001 |
| P (mmol/L) | 1.82(1.52, 2.26) | 1.67(1.49, 1.91) | 1.97(1.53, 2.53) | 0.039 |
| iPTH (pg/mL) | 245.4 0(122.35, 864.75) | 165.00(79.53, 274.80) | 745.60(162.30, 1775.00) | < 0.001 |
| ALP(U/L) | 75.00(60.00, 146.25) | 73.00(59.00, 91.00) | 110.00(60.00, 353.00) | 0.019 |
| K (mmol/L) | 5.02(4.44, 5.51) | 4.86(4.45, 5.73) | 5.10(4.40, 5.45) | 0.943 |
| HCO3−(mmol/L) | 20.04 ± 3.25 | 20.21 ± 2.90 | 19.91 ± 3.53 | 0.716 |
| BUN (mmol/L) | 24.66 ± 6.09 | 23.50 ± 5.79 | 25.55 ± 6.24 | 0.191 |
| Cr (μmol/L) | 786.50(680.60, 922.00) | 707.00(535.00, 752.00) | 884.00(754.00, 1038.00) | < 0.001 |
| Alb(g/L) | 41.1(39.0, 43.75) | 39.30(35.30, 42.10) | 42.1(39.8, 44.60) | 0.005 |
| LDL (mmol/L) | 2.04 ± 0.59 | 2.02 ± 0.67 | 2.06 ± 0.52 | 0.800 |
| TG (mmol/L) | 1.22(0.88,1.77) | 1.12(0.88,1.75) | 1.29(0.88,2.17) | 0.247 |
| SF (ng/mL) | 155.10(80.13, 317.25) | 135.87(83.65, 249.71) | 197.64(78.19, 405.49) | 0.089 |
| Hb(g/L) | 112.00(100.00, 121.25) | 117.00(100.00, 124.00) | 111.00(100.00, 119.00) | 0.259 |
| WBC(910^9/L) | 6.06(4.55,7.37) | 6.62(5.47, 7.98) | 5.11(4.23, 7.29) | 0.025 |
| PLT(510^9/L) | 189.50(160.00, 22D1.75) | 203.00(145.00, 247.00) | 184.00(164.00, 199.00) | 0.338 |
| Dialyzer membrane | ||||
| CTA, (%) | 35.5 | 22.2 | 45.7 | 0.048 |
| PS, (%) | 54.8 | 63.0 | 48.6 | 0.192 |
| PMMA, (%) | 9.7 | 14.8 | 5.7 | 0.221 |
| Calciums, (%) | 79.0 | 66.7 | 88.6 | 0.037 |
| Calcium free phosphorus binders carbonate) | ||||
| Sevelamer, (%) | 25.8 | 3.7 | 42.9 | < 0.001 |
| Lanthanum carbonate, (%) | 16.1 | 18.5 | 14.3 | 0.735 |
| Active vitamin D, (%) | 29.0 | 7.4 | 45.7 | 0.001 |
| Paricalcitol, (%) | 8.1 | 3.7 | 11.4 | 0.376 |
| Statins, (%) | 16.1 | 33.3 | 2.9 | 0.002 |
Continuous variables are expressed as mean ± standard deviation for normally distributed variables and as median (interquartile range) for variables with skewed distribution. Differences between patients with and without diabetes were assessed using the t test, Mann–Whitney U test or Chi-square analysis, as appropriate. Values with p < 0.05 were considered statistically significant and are indicated in bold
MHD maintenance hemodialysis, SBP systolic blood pressure, DBP diastolic blood pressure, CHD Coronary heart disease, NGAL neutrophil gelatinase-associated lipocalin, Ca calcium, P phosphate, iPTH intact parathyroid hormone, ALP alkaline phosphatase, K potassium, HCO3- carbonate ion, BUN blood urea nitrogen, Cr creatinine, Alb albumin, LDL low density lipoprotein, TG triglyceride, SF serum ferritin, Hb hemoglobin, WBC white blood cells, PLT platelet, HD hemodialysis, HFD high-flux hemodialysis, HDF hemodiafiltration, CTA cellulose triacetate, PS polysulfone, PMMA polymethylmethacrylate