Table 1.

Evolution of ciprofloxacin resistance over time. The isolates that were subjected to WGS are colored in grey. Asterisk denotes bacterial cell death. X: data not recorded. Asterisk denotes bacterial cell death.

WHO Reference Strains	CIP MIC (mg/L)																					Total No. of Passages
WHO-F1	0.004	X	X	X	X	0.032	0.032	0.047	X	0.047	X	0.125	*									5
WHO-F2	0.004	0.064	X	X	0.064	0.064	X	0.094	X	0.094	X	X	0.38	X	0.75	4	X	12	*			9
WHO-F3	0.004	0.006	X	X	0.047	0.032	X	0.064	X	X	0.125	*										5
WHO-P1	0.004	0.008	X	X	0.012	0.125	*															3
WHO-P2	0.004	0.125	X	X	0.125	0.25	X	1.5	1	X	1.5	X	X	X	X	4	*					7
WHO-P3	0.004	0.125	X	X	0.125	X	0.5	X	X	X	2	4	4	X	X	16	X	32	X	X	32	9
Days	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21