Comparison between the relative errors (REs) and target registration errors (TREs) for images and deformation vector fields (DVFs) solved by 2D3D-RegNet, using different offset angles at test time. Four scan angle scenarios were included in this evaluation: single-view 30°, ortho-view 30°, single-view 90° and ortho-view 90° (Fig. 3). The networks were separately trained on the four scan angle scenarios, with angle directions specified in Fig. 3. During testing, the scan angles were collectively offset by magnitudes ranging from 0° to 25°.