Figure 2.

Schwann cells from L1/858–868 and L1/687 mice were not stimulated by antibody 557 or duloxetine. Schwann cells were prepared from 6- to 7-day-old male wild-type (WT, white bars) and L1 mutant littermate (gray bars) mice and seeded on a PLL substrate. Process lengths were determined after treatment without (−) or with 50 µg/mL of antibody 557 (557) or 100 nM of duloxetine (dulo) for 24 h. Values were obtained from three independent experiments analyzing 100 cells per genotype and condition for each experiment. Values show the means ± SD. ** p < 0.01 difference relative to PLL, # p < 0.05 difference relative to the wild-type (two-way ANOVA with Tukey´s post-hoc test).