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. 2022 Apr 14;23(8):4337. doi: 10.3390/ijms23084337

Figure 4.

Figure 4

Mitochondria from L1/687 and L1/858-863 mice show a reduced membrane potential. (A) Mitochondrial Complex I activity was determined using isolated mitochondria from whole brains of 7- to 9-day-old male L1/687, L1/858-863 (gray bars) and wild-type (WT, white bars) littermate mice. (B,C) Mitochondrial ATP levels (B) and mitochondrial membrane potential (C) were determined in cultured cerebellar neurons from 7-day-old male L1/687, L1/858-863 (gray bars) and wild-type littermate (WT, white bars) mice. Means ± SD (C) or means ± SEM and values from individual mice (A,B) are shown; L1/687: n = 6 for Complex I activity, n = 3 for ATP level and membrane potential; L1/858-863: n = 4 for Complex I activity, n = 6 for ATP levels and n = 3 for membrane potential. * p < 0.05, ** p < 0.01, *** p < 0.005 (Mann–Whitney test).