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. 2022 Apr 10;14(8):1919. doi: 10.3390/cancers14081919

Figure 2.

Figure 2

Imaging results of patients with severe CNS neurotoxicities during immunotherapy with DB and scIL-2. (A) Patient 1. MRI of brain showing inflammation and oedema of mesencephalon, pons and medulla oblongata. (B) Patient 3. Frontal and sagittal MRI of spinal cord, with hyperintensive zone in STIR- and T2-weighted images. (C,D) Patient 2 and 4, respectively. Sagittal MRI of spinal cord, with hyperintensive zone in T2-weighted images. Arrows indicate areas of inflammatory response. DB, dinutuximab beta; CNS, central nervous system; MRI, magnetic resonance imaging; scIL-2, subcutaneous interleukin-2; STIR, short-TI inversion recovery.