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. 2022 Apr 10;14(8):1919. doi: 10.3390/cancers14081919

Table 1.

Criteria of severe CNS neurotoxicity.

Clinical Symptoms of CNS Dysfunction Radiological Signs

  • Muscle paresis and/or paraplegia

  • CNS inflammation and/or demyelination

  • Urinary retention/neurogenic bladder not associated with morphine use

  • Coma

  • Seizures

  • Cranial nerve palsy

  • Ataxia

CNS, central nervous system.