TABLE 3.
Reduction in bacterial counts of pure or mixed cultures of B. fragilis, VREF, E. faecium, or E. coli strainsa
| Culture | Avg reduction(s) in bacterial counts (log10 CFU/ml ± SD) compared to those of controls b |
|---|---|
| B. fragilis ATCC 23745 | 5.3 ± 1.0 |
| B. fragilis ATCC 25285 | 6.6 ± 0.3 |
| VREF BM4147 | 0.9 ± 0.2 |
| E. faecium SH17 | 1.0 ± 0.3 |
| E. coli 29020 | 0.1 ± 0.1 |
| B. fragilis ATCC 23745 + VREF BM4147 | 2.4 ± 0.2c/0.8 ± 0.5 |
| B. fragilis ATCC 23745 + E. faecium SH17 | 3.0 ± 0.4d/1.0 ± 0.3 |
| B. fragilis ATCC 23745 + E. coli 29020 | 2.2 ± 0.3c/0.1 ± 0.1 |
| B. fragilis ATCC 25285 + VREF BM4147 | 3.4 ± 0.3c/0.9 ± 0.5 |
| B. fragilis ATCC 25285 + E. faecium SH17 | 3.9 ± 0.3c/1.0 ± 0.2 |
| B. fragilis ATCC 25285 + E. coli 29020 | 4.0 ± 0.2c/0.1 ± 0.1 |
a
Counts were taken after a 24-h incubation with 2 μg of trovafloxacin/ml and were determined by the time-kill technique.
b
Reductions are averages of three experiments using inocula of 108 CFU/ml.
c
Significantly different from counts obtained with pure cultures of B. fragilis (P < 0.001).
d
Significantly different from counts obtained with pure cultures of B. fragilis (P < 0.01).