Table 2.
The in vitro investigated results of different formulations (FN1-FN17) for responses Y1, Y2, and Y3 in Box Behnken design for optimization of β-Sitosterol-loaded Alg/Ch-NPs-FA.
| Formulation Code | Independent Variables | Responses | ||||
|---|---|---|---|---|---|---|
| X1 (% w/v) | X2 (% w/v) | X3 (mM) | Y1 (nm) | Y2 (%) | Y3 (%) | |
| FN1 | 0.10 | 0.40 | 16.00 | 121 | 90 | 70 |
| *FN2 | 0.20 | 0.40 | 24.00 | 142 | 72 | 49 |
| FN3 | 0.30 | 0.60 | 24.00 | 166 | 80 | 54 |
| FN4 | 0.10 | 0.20 | 24.00 | 151 | 86 | 55 |
| *FN5 | 0.20 | 0.40 | 24.00 | 137 | 73 | 47 |
| FN6 | 0.20 | 0.60 | 16.00 | 170 | 87 | 37 |
| *FN7 | 0.20 | 0.40 | 24.00 | 145 | 74 | 49 |
| FN8 | 0.10 | 0.60 | 24.00 | 123 | 93 | 74 |
| FN9 | 0.30 | 0.40 | 32.00 | 146 | 72 | 72 |
| FN10 | 0.20 | 0.60 | 32.00 | 168 | 75 | 52 |
| FN11 | 0.20 | 0.20 | 16.00 | 139 | 78 | 40 |
| *FN12 | 0.20 | 0.40 | 24.00 | 140 | 74 | 48 |
| FN13 | 0.10 | 0.40 | 32.00 | 149 | 70 | 77 |
| FN14 | 0.20 | 0.20 | 32.00 | 180 | 78 | 38 |
| *FN15 | 0.20 | 0.40 | 24.00 | 146 | 71 | 47 |
| FN16 | 0.30 | 0.40 | 16.00 | 138 | 67 | 58 |
| FN17 | 0.30 | 0.20 | 24.00 | 131 | 79 | 58 |
X1: Chitosan (% w/v); X2: Sodium alginate (% w/v); X3: Calcium chloride (mM); Y1: Particle size (nm); Y2: %Drug encapsulation; Y3: %Cumulative drug release.*Replicas.