Table 2.
In vitro drug membrane parameters of resatorvid topical creams and lotion formulations through Strat-M® transdermal diffusion membrane (n = 3, mean ± standard deviation). Lowercase letters indicate differences between formulations with the same concentration. Capital letters indicate difference between concentrations in the same formulation (p < 0.05).
| 5% Creams and Lotions | Flux (µg/cm2/h) | Lag Time (h) | Drug Retention (µg) |
|---|---|---|---|
|
5% (w/w) DermaBaseTM (cream formulation) |
8.72 ± 2.59 a A | - | 409.24 ± 12.67 a A |
|
5% (w/w) DermaBaseTM (lotion formulation) |
6.03 ± 2.01 a A | - | 570.7 ± 55.87 b A |
|
5% (w/w) PENcreamTM (cream formulation) |
1.68 ± 0.30 b A | - | 397.63 ± 16.22 a A |
| 2.5% creams and lotions | Flux (µg/cm2/h) | Lag time (h) | Drug retention (µg) |
|
2.5% (w/w) DermaBase (cream formulation) |
3.70 ± 0.64 a B | - | 376.03 ± 50.36 ab A |
|
2.5% (w/w) DermaBaseTM (lotion formulation) |
2.85 ± 0.37 a B | - | 417.97 ± 24.26 b B |
|
2.5% (w/w) PENcreamTM (cream formulation) |
1.66 ± 0.65 a A | - | 326.89 ± 24.56 a A |
| 1.25% creams and lotions | Flux (µg/cm2/h) | Lag time (h) | Drug retention (µg) |
|
1.25% (w/w) DermaBaseTM (cream formulation) |
2.82 ± 0.69 a B | - | 199.43 ± 16.63 a B |
|
1.25% (w/w) DermaBaseTM (lotion formulation) |
1.98 ± 0.29 a B |
- | 153.50 ± 32.36 a C |
|
1.25% (w/w) PENcreamTM (cream formulation) |
2.03 ± 0.13 a A | - | 204.56 ± 12.16 a B |