Table 3.
In vitro drug membrane parameters of resatorvid topical simple solutions through Strat-M® transdermal diffusion membrane (n = 3, mean ± standard deviation). Lowercase letters indicate differences between formulations with the same concentration. Capital letters indicate differences between concentrations in the same formulation (p < 0.05).
| 5% Simple Solutions | Flux (µg/cm2/h) | Lag Time (h) | Drug Retention (µg) |
|---|---|---|---|
| 5% (w/v) PEG-400 solution | 5.33 ± 1.05 a A | 2.4 ± 0.29 | 556.76 ± 47.72 a A |
| 5% (w/v) PG solution | 57.10 ± 3.90 b A | - | 1686 ± 285.15 b A |
| 2.5% simple solutions | Flux (µg/cm2/h) | Lag time (h) | Drug retention (µg) |
| 2.5% (w/v) PEG-400 solution | 9.16 ± 1.39 a A | 0.83 ± 0.15 | 498.21 ± 37.7 a A |
| 2.5% (w/v) PG solution | 47.87 ± 3.69 b B | - | 1242.88 ± 63.76 b B |
| 1.25% simple solutions | Flux (µg/cm2/h) | Lag time (h) | Drug retention (µg) |
| 1.25% (w/v) PEG-400 solution | 3.60 ± 1.5 a A | 1.14 ± 0.34 | 264.63 ± 9.47 a A |
| 1.25% (w/v) PG solution | 5.33 ± 1.05 a C | - | 938.08 ± 56.73 b B |