Table 4.
In vitro drug membrane parameters of resatorvid topical gels/serum formulations through Strat-M® transdermal diffusion membrane (n = 3, mean ± standard deviation). Lowercase letters indicate differences between formulations with the same concentration. Capital letters indicate differences between concentrations in the same formulation (p < 0.05).
| 2.5% Gels and Serum | Flux (µg/cm2/h) | Lag Time (h) | Drug Retention (µg) |
|---|---|---|---|
| 2.5% (w/w) Carbomer (gel formulation) |
5.76 ± 2.08 a A | - | 638.51 ± 32.19 a A |
| 2.5% (w/w) Hyaluronic Acid (gel/serum formulation) |
0.52 ± 0.14 b A | 1.14 ± 0.25 | 472.36 ± 52.29 b A |
| 2.5% (w/v) Pluronic® F-127 (gel formulation) |
8.5 ± 0.39 a A | - | 289.72 ± 20.46 c A |
| 1.25% gels and serum | Flux (µg/cm2/h) | Lag time (h) | Drug retention (µg) |
| 1.25% (w/w) Carbomer (gel formulation) |
2.77 ± 0.80 a A | 0.15 ± 0.07 | 445.06 ± 85.12 a B |
| 1.25% (w/w) Hyaluronic Acid (gel/serum formulation) |
1.16 ± 0.19 a A | 1.98 ± 0.34 | 415.83 ± 21.19 a A |
| 1.25% (w/v) Pluronic® F-127 (gel formulation) |
8.45 ± 1.51 b A | - | 235.06 ± 45.74 c A |