Table 5.
In vitro drug membrane parameters of resatorvid topical formulations through EpiDermTM -D normal human derived epidermal keratinocytes as models for transdermal diffusion (n = 3, mean ± standard deviation).
| 1.25% Creams and Lotion | Flux (µg/cm2/h) | Lag Time (h) | Drug Retention (µg) |
|---|---|---|---|
| 1.25% (w/w) DermaBASETM (cream formulation) |
2.56 ± 0.68 | - | 14.24 ± 2.54 |
| 1.25% (w/w) DermaBASETM (lotion formulation) |
1.97 ± 0.38 | 0.20±0.08 | 9.38 ± 2.56 |
| 1.25% (w/w) PENcreamTM (cream formulation) |
7.9 ± 1.90 | - | 19.69 ± 2.16 |
| 1.25% simple solutions | Flux (µg/cm2/h) | Lag time (h) | Drug retention (µg) |
| 1.25% (w/v) PEG-400 solution | 2.39 ± 0.68 | 0.37 ± 0.11 | 21.35 ± 6.54 |
| 1.25% (w/v) PG solution | 11.08 ± 2.92 | 0.50 ± 0.16 | 43.07 ± 6.91 |
| 1.25% gels and serums | Flux (µg/cm2/h) | Lag time (h) | Drug retention (µg) |
| 1.25% (w/w) Carbomer (gel formulation) |
5.34 ± 1.27 | - | 51.06 ± 12.4 |
| 1.25% (w/w) Hyaluronic Acid (gel/serum formulation) |
6.53 ± 0.769 | 0.36 ± 0.0.18 | 24.02 ± 6.63 |
| 1.25% (w/v) Pluronic® F-127 (gel formulation) |
6.37 ± 0.47 | - | 18.52 ± 2.08 |