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. 2022 Apr 12;14(8):1932. doi: 10.3390/cancers14081932

Figure 2.

Figure 2

Gut microbiota diversity in pediatric allo-HSCT patients with different duration of febrile neutropenia. (A) PCoA based on weighted UniFrac distances between the gut microbiota profiles of samples collected before transplant (PRE), at the onset of neutropenia (day −2/+2; P2), at the onset of fever (day +4/+5; P5), at engraftment (TAKE) and after engraftment (day +20/+30; P20), in pediatric allo-HSCT patients with less than or equal to (left) and more (right) than three days of fever. Ellipses include 95% confidence area based on the standard error of the weighted average of sample coordinates. Significant separation among groups was found only for patients with longer fever duration (permutation test with pseudo-F ratio, p = 0.03). See also Supplementary Figure S2; (B) Boxplots showing the dynamics of alpha diversity, estimated with the Shannon index (left) and the number of observed ASVs (right), in patients with less than or equal to vs. more than three days of fever. Wilcoxon test, * for p < 0.05, ** for p < 0.01.