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Number of survivors in different groups of untreated and HMR 3004-treated infected mice. HMR 3004 was delivered by gavage at a dose of 25 mg/kg (12.5 mg/kg/day given twice a day), started 24, 48, or 72 h after intranasal inoculation of animals with 107 S. pneumoniae bacteria. Twelve mice per group were infected to determine survival rate.
