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Mean (±SEM) blood leukocyte counts (A) and MPO levels (B) in lung homogenates of infected and healthy mice, treated or not with HMR 3004 at 25 mg/kg/day. Significant leukopenia was seen in the untreated infected mice from 24 to 36 h after initiation of treatment (which was started 48 h p.i.) compared to the healthy controls or the HMR 3004-treated infected mice. Recruitment of PMNs to the lung (MPO levels) was greatly reduced by HMR 3004. ∗, P < 0.05.
