Table 6.

Clinical data and oculomotor performance of bulbar-onset and spinal-onset ALS patients.

		Bulbar Onset (n = 12)	Spinal Onset (n = 48)	p-Value
Age, y		58.17 ± 11.58	53.40 ± 10.60	0.176
Sex, male/female		8 (66.7%)/4 (33.3%)	22 (45.8%)/26 (54.2%)	0.197
Age of onset, y		61.50 (45.00, 66.25)	51.00 (44.25, 60.50) a	0.109
Disease duration, mo		11.50 (9.00, 30.00)	20.00 (11.00, 33.75)	0.242
ALSFRS-R total score		40.00 (38.00, 44.50)	40.00 (35.50, 42.50)	0.358
ΔALSFRS-R		0.33 (0.23, 0.86)	0.58 (0.21, 0.88) a	0.746
Gaze test	Square-wave jerks	9 (75.0%)	23 (47.9%)	0.115
Reflexive saccade test	Hypometria	1 (8.3%)	5 (10.4%)
	Latency, ms	322.17 ± 37.18	347.58 ± 48.91	0.100
	Velocity, °/s	554.00 ± 133.28	587.84 ± 108.60	0.365
Smooth pursuit test	Abnormal cogwheeling	8 (66.7%)	22 (45.8%)	0.333
	Velocity gain toward left	0.85 (0.83, 0.87) a	0.85 (0.82, 0.88)	0.844
	Velocity gain toward right	0.84 (0.82, 0.87) a	0.85 (0.82, 0.86)	0.783

Data are presented as the mean ± standard deviation, median (first quartile, third quartile), or N (%). Abbreviations: ALS, amyotrophic lateral sclerosis; ALSFRS-R, Amyotrophic Lateral Sclerosis Functional Rating Scale—Revised. a, Normally distributed data but summarized here as the median (first quartile, third quartile).