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. 2022 Mar 29;14(4):736. doi: 10.3390/pharmaceutics14040736

Figure 5.

Figure 5

ARC decreases the amount of vWF released by endothelial cells. HUVEC were (A) unstimulated or stimulated with (B) LPS (1 μg/mL); (C) Pam3CSK4 (1 μg/mL); (D) TNF-α (3 ng/mL) or (E) IL-1β (1 ng/mL) and incubated with nanoarchaeosomes (ARC) or liposomes (LIP) at a concentration of 50 μg/mL for 1 and 18 h. The vWF concentrations in the supernatants were determined by ELISA (one-way ANOVA followed by Bonferroni multiple comparisons test; * p < 0.05 vs. basal; # p < 0.05 and ## p < 0.01 between the labeled groups). Results are the mean ± SEM of four to five independent experiments.