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ARC are internalized by HUVEC. HUVEC were incubated for 1, 4 and 18 h with RhPE-labeled nanovesicles (ARC-RhPE and LIP-RhPE). Uptake assays were performed by (A) flow cytometry (one-way ANOVA followed by Bonferroni multiple comparisons test; * p < 0.05, ** p < 0.01, *** p < 0.01 and **** p < 0.001 between the labeled groups) and (B) Confocal microscopy. Representative images show RhPE-nanovesicles (red) and cytoplasm (green, FITC-phalloidin staining). Scale bars: 10 μm.
