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. 2022 Apr 13;15(4):473. doi: 10.3390/ph15040473

Figure 1.

Figure 1

Effects of a single administration of cannabidiol (CBD) (10, 20 and 30 mg/kg, i.p.) on anxiety-like behaviors in the light-dark box (A,B) and elevated plus maze (C,D) paradigms. The behavioral evaluation was developed 1 h and 30 min after the administration of CBD (or vehicle (VEH)). Columns represent the means and vertical lines ± SEM of (A) the time in the lighted box (s); (B) the number of transitions in the light-dark box test; (C) the percentage of time in the open arms (%); and (D) the number of transitions in the elevated plus-maze test. * Values from CBD-treated mice that were different (p < 0.05) from VEH-treated mice and # values from CBD-20 mg/kg-treated mice that were different from CBD-10 mg/kg-treated mice (one-way ANOVA followed by Student–Newman–Keuls test, p < 0.05).