Figure 2.

EndoCBs synthesis, degradation and distinct MAGL and FAAH profiles in migraine pain pathways. (A) Main enzymatic steps of 2-AG and AEA synthesis and degradation. (B) Text size of enzymes and endoCBs is used to emphasize the relative enzymatic activity and endoCBs levels in the trigeminal ganglion and in cortex. On the left, MAGL, in contrast to FAAH, is the prevalent endoCBs hydrolysing enzyme in the trigeminal ganglion, whereas, in the brain (on the right), both MAGL and FAAH are highly active. Despite the high active state of both FAAH and MAGL in the brain, due to higher synthesis, the basic level of 2-AG in the brain is much higher than that of AEA. In contrast, in the trigeminal ganglion, the level of AEA appears to be high due to lower FAAH activity.