Table 3.

Pharmacokinetics parameters of flomoxef.

Pharmacokinetics Parameter Calculation Formula for Flomoxef by Renal Function; as a 1 h Infusion of Flomoxef 1 g
		n	T1/2 (β) (h)	Model
Healthy		25	0.82	CL (L/h) = Vc × K10
Renal dysfunction				CL conversion formula
	5 ≦ CCR ≦ 20	4	6.95	CL severe = CL healthy × (1/0.82)/6.95
	(severe)
	20 < CCR ≦ 40	10	2.48	CL mild = CL healthy × (1/0.82)/2.48
	(mild)
	40 < CCR ≦ 70	10	1.57	CL medium = CL healthy × (1/0.82)/1.57
	(medium)

CCR: creatinine clearance (mL/min), Vc: total volume distribution (1-compartment model).