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. 2022 Apr 22;21:103. doi: 10.1186/s12943-022-01524-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — In vivo study of the function of gene cdk6 to regulate drug-resistance of KB-C2 tumors. A Image of the tumors from the tumor-bearing mice showing the tumor morphology and the fluorescent DOX (depicted with yellow-green arrows) accumulated in the cdk6-present or cdk6-deficient tumors. The mice treated with saline were set as the blank control group. The tumors were sampled by the 19th day of DOX treatment. B Increased tumor sizes after the mice received chemotherapy using DOX. The mice treated with saline were set as the blank control group. C Comparison of the relative fluorescent intensity showing the difference of DOX accumulation in the cdk6-present or cdk6-deficient tumors. D Pathology of main organs of the mice bearing KB-C2 or KB-C2-k.o.cdk6 tumors. The organs were sampled by the 19th day after DOX treatment. The circle in black depicts focal infiltration of peri-bronchial inflammatory cells. The arrows in red depicts white pulp germinal center expansion, which occurred frequently in the tumor-bearing mice untreated with DOX, but only occasionally detected in the DOX-treated mice bearing KB-C2-k.o.cdk6