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. 2022 Apr 9;14(8):1897. doi: 10.3390/cancers14081897

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TSA and SAHA significantly modulate GBM cell transcription. (A) Heatmap displaying hierarchical clustering of control and HDI-treated GBM cells (5 μM for 24 h) according to the top variable transcripts. (B) Dot plot showing significant (FDR q value < 0.05) transcriptional enrichments (C2cp MSigDB) of common DEGs between TSA and SAHA treated cells as in (A). (C) Heatmap displaying relative enrichment of each sample subjected to GEP in the four different GBM molecular subtypes [2] from the C2cgp MSig database.