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. 2022 Mar 30;11(4):663. doi: 10.3390/antiox11040663

Figure 2.

Figure 2

Schematic representation of NRF2 modulation. Vitamin C, SB216763, resveratrol, melatonin, epigallocatechin-3-gallate and theaflavins increase NRF2 expression in ovarian cells improving their response to oxidant agents. In ovarian cancer cells, increased levels of miR-181d, Lin-H19, p62, SIRT5, PUMA and KEAP1/CUL3/RBX1 alterations lead to an increase in NRF2 expression. However, decreased levels of NRF2 lead to an increased expression of ERα, PGR, SLC40A1, miR-206 and decreased expression of CD99, ErbB2 and AKR1C1-3. In addition, NRF2 indirectly decreases c-MET and EGFR expression by increasing miR-206 levels.