. 2022 Mar 31;11(4):692. doi: 10.3390/antiox11040692

Table 1.

Inducers and inhibitors of ferroptosis.

Small Molecules/Chemicals	Mechanisms/Target	Effects on Ferroptosis	Reference
Erastin	Inhibit system X_c	Induce	[147]
Sorafenib	Inhibit system X_c	Induce	[148]
Sulfasalazine	Inhibit system X_c	Induce	[149]
Glutamate	Inhibit system X_c	Induce	[150]
RSL3	Block GPx4	Induce	[135]
ML162	Block GPx4	Induce	[136]
ML210	Block GPx4	Induce	[137]
NSC144988	Block GPx4	Induce	[138]
Ferrostatin1	Radical trapping of lipid peroxide	Inhibit	[151]
Liprostatin1	Radical trapping of lipid peroxide	Inhibit	[151]
α-Tocophenol	Radical trapping of lipid peroxide	Inhibit	[23]
Idebenone	CoQ₁₀ anolog- Radical trapping of lipid peroxide	Inhibit	[152]
4-Chlorobenzoic acid	Block CoQ₁₀ pathway	Induce	[140]
iFSP1	Block CoQ₁₀ pathway	Induce	[139]
Deferoxamine	Iron chelator	Inhibit	[23]