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Model for elastic fibre assembly. Both fibulin-4 and fibulin-5 and their complexes with tropoelastin bind to LTBP4, and tropoelastin can also bind directly to LTBP4. These complexes mediate the deposition of elastin onto a fibrillin microfibril scaffold, supported by molecular interactions between fibrillin, tropoelastin, LTBP4, fibulin-4 and -5, as detailed in Table 1.
