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. 2022 Mar 25;14(4):683. doi: 10.3390/v14040683

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Competing circRNA–miRNA–mRNA network analysis identified a connection between the circRNAs exclusive to all 19 viremic patients and post-transcriptional control of genes governing transcription of host and pro-viral RNAs. (A) The miRNAs predicted to competitively target circRNA–MRE and host mRNA–MRE. Orange circles, MRE cognate miRNA from Table 2 exhibited complementarity to candidate circRNA. Light blue squares, mRNA that had an MRE targeted by the indicated miRNA. Purple lines, connections between the nodes. (B) Enhanced stringency network: mRNAs containing at least 3 MREs from (A). Black box, MRE cognate miRNA from Table 2; Octagons, host mRNA from (A) that were targeted by three or more cognate miRNAs in common with circRNA. (C) Top GO terms of mRNA identified in the enhanced stringency network in (B). p-values are listed on the right vertical axis.

Competing circRNA–miRNA–mRNA network analysis identified a connection between the circRNAs exclusive to all 19 viremic patients and post-transcriptional control of genes governing transcription of host and pro-viral RNAs. (A) The miRNAs predicted to competitively target circRNA–MRE and host mRNA–MRE. Orange circles, MRE cognate miRNA from Table 2 exhibited complementarity to candidate circRNA. Light blue squares, mRNA that had an MRE targeted by the indicated miRNA. Purple lines, connections between the nodes. (B) Enhanced stringency network: mRNAs containing at least 3 MREs from (A). Black box, MRE cognate miRNA from Table 2; Octagons, host mRNA from (A) that were targeted by three or more cognate miRNAs in common with circRNA. (C) Top GO terms of mRNA identified in the enhanced stringency network in (B). p-values are listed on the right vertical axis.