Figure 5.

CircRNAs contain MREs previously identified in the HIV-1 3’-untranslated region (UTR). (A) HIV-1 precursor RNA is processed into 3 categories of mRNA: completely spliced, MS; incompletely spliced, SS; unspliced, US. Grey rectangles, the 5’-UTR; black rectangles, 3’ UTRs; labeled boxes, open reading frames;thin lines, excised introns;blue vertical lines, MREs designated by cognate miRNA; MRE coordinates; orange box, position of 5’ and 3’ long terminal repeats (LTR) in the precursor RNA to all mRNAs; RRE, Rev responsive element. (B) The interaction network posits the six MRE in HIV-1 (A) are incommon with the indicated host mRNAs (pink boxes). Each gene locus exhibited 3 or more copies of the candidate MRE for each cognate host miRNA (black outline). Names of genes are listed Table S3.