Table 2.
Competing RNA interactors are proposed by network analysis of candidate circRNA exclusive to 19 viremic patients.
| Designation Role of Parental Gene Locus |
MREs Identified in Host circRNA | MRE Identified in HIV-1 3’UTR |
Anti-HIV-1 Activity of Cognate miRNA |
Frequency of Host mRNAs with MREs | Other Virus-Related Activity of Cognate miRNA |
|---|---|---|---|---|---|
| circANKRD17 Upregulates dsRNA receptor DDX58 and IFIH1 signaling pathways in antiviral innate immune response |
hsa-miR-105-5p | Not identified | Not identified | 231 | Not identified |
| hsa-miR-128-3p | Not identified | Not identified | 464 | Herpesvirus 1, Influenza A virus, Murine gammaherpesvirus 68, Respiratory syncytial virus |
|
| hsa-miR-140-5p | Yes | Not identified | 91 | Classical swine fever virus, Mink enteritis virus |
|
| hsa-miR-141-5p | Not identified | Not identified | 101 | Enteroviruses, Epstein–Barr virus |
|
| hsa-miR-197-3p | Yes | Maybe | 106 | Enteroviruses, Hepatitis B virus, SARS-CoV2 |
|
| hsa-miR-203a-5p | Not identified | Not identified | 61 | Hepatitis C virus, Influenza A virus, Sendai virus |
|
| circHIPK3 Regulates transcription and apoptotic pathways |
hsa-miR-17-3p | Not identified | Not identified | 146 | Not identified |
| hsa-miR-143-5p | Not identified | Not identified | 133 | Influenza A virus | |
| hsa-miR-150-3p | Yes | Yes | 132 | Dengue virus, SARS-CoV2 |
|
| circPHC3 Maintains repressed state of genes through chromatin remodeling and histone modification |
hsa-miR-141-5p | Not identified | Yes | 101 | Enteroviruses, Epstein–Barr virus |
| hsa-miR-145-5p | Not identified | Not identified | 311 | Hepatitis C virus, Zika virus, SARS-CoV2 |
|
| hsa-miR-197-3p | Yes | Maybe | 106 | Enteroviruses, Hepatitis B virus, SARS-CoV2 |
|
| hsa-miR-219-a-1-3p | Not identified | Not identified | 66 | Avian Influenza virus, SARS-CoV2 |
|
| circSATB1 Regulates chromatin structure and remodeling |
hsa-miR-22-5p | Not identified | Not identified | 150 | Not identified |
| hsa-miR-125b-2-3p | Yes | Yes | 141 | Hepatitis C virus, Japanese encephalitis virus |
|
| hsa-miR-224-5p | Yes | Not identified | 183 | Hepatitis B virus | |
| circZNF609 Binds promoters with paused Pol II |
hsa-miR-26b-3p | Not identified | Not identified | 106 | Newcastle disease virus, Sendai virus, Vesicular stomatitis virus |
| hsa-miR-149-5p | Yes, twice | Yes | 155 | Hantaan virus, Influenza A virus |
|
| circATXN1 circFAM13B circFBXW7 |
None identified | N/A | N/A | N/A | N/A |