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. 2022 Apr 9;11(8):1284. doi: 10.3390/cells11081284

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Total protein extracts obtained from head tissues of elav-Gal4/+ and elav-Gal4 > Aβ42 flies, treated or not with PARP-1 inhibitors olaparib (A) or MC2050 (B), were resolved by SDS-PAGE, transferred onto PDVF membrane and probed with antibodies against histone H3 trimethylated in lysine 9 (H3K9me3), trimethylated in lysine 27 (H3K27me3) and histone H3 pan-acetylated (H3 pan-Ac). Densitometry analysis was performed using ImageLab software and normalized to H3. The data are expressed as a percentage of the elav-Gal4/+ control values and represent the mean ± SEM of at least three independent experiments. Statistical significance was determined using the two-way ANOVA test followed by the Tukey test for multiple comparisons. (* p < 0.05; ** p < 0.01; *** p < 0.001.)