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. 2022 Apr 9;11(8):1284. doi: 10.3390/cells11081284

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Climbing test on AD APP/BACE1 flies with neuron-specific depletion of PARP-1 by RNAi. Statistical significance was determined using the one-way ANOVA test followed by the Tukey test for multiple comparisons (* p < 0.01; *** p < 0.001). (B) Survival curves of AD APP/BACE1 flies with neuron-specific depletion of PARP-1 by RNAi and related controls. The log-rank (Mantel–Cox) test with Bonferroni correction for multiple comparisons indicates a significant difference between all survival curves (*** p < 0.001). (C) Survival curves of AD APP/BACE1 flies treated with 25 µM olaparib and related controls. The log-rank (Mantel–Cox) test with Bonferroni correction for multiple comparisons indicates a significant difference between all survival curves (* p < 0.01) except for elav-Gal4/+ DMSO vs. elav-Gal4/+ OLA. (D) Survival curves of AD APP/BACE1 flies treated with 50 µM MC2050 and related controls. The log-rank (Mantel–Cox) test with Bonferroni correction for multiple comparisons indicates a significant difference between all survival curves (*** p < 0.001).