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. 2022 Mar 25;12(4):288. doi: 10.3390/metabo12040288

Figure 2.

Figure 2

Results of activity testing of Lonicera ethanolic leaf extracts 1–36 (colored according to species) on the production of inflammation mediators. (A) Effect on IL-8 expression in HUVECtert cells stimulated with LPS. Extract concentration: 50 µg/mL; positive control: Bay 11-7082 (7.5 µM); results are given as the means ± SD of 6 replicates. (B) Effect on NO production in LPS/IFNγ-stimulated RAW macrophages. Extract concentration: 50 µg/mL; Positive control: L-NMMA (100 µM); results are given as the means ± SD of three experiments performed in duplicates. (C) Effect on NF-κB transactivation and on cell viability in HEK/NFκB-luc cells stimulated with TNF-α; extract concentration: 50 µg/mL; positive control: parthenolide (5 µM). Results are given as the means ± SD of 4 replicates (each in quadruplicate).