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. 2022 Apr 12;10(4):881. doi: 10.3390/biomedicines10040881

Figure 4.

Figure 4

The reduction of VMAT2 levels in G2019S KI mice appears at 12 months and is associated with the G2019S mutation. Western blot analysis of VMAT2 levels in the striatum of 6-month-old (A), 9-month-old (B), 12-month-old (C) and 18-month-old (D) G2019S KI mice versus age-matched WT controls, and representative blots. (E) Western blot analysis of VMAT2 levels in the striatum of 12-month-old G2019S KI mice versus age-matched LRRK2 KO, KD and WT mice, and representative blots. Data are expressed as mean ± SEM of n = 6 animals per group. Statistical analysis was performed using the Student t-test, two-tailed for unpaired data (A–D) or one-way ANOVA (E) followed by the Tukey test for multiple comparisons. * p < 0.05, ** p < 0.01 different from WT.