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. 2022 Apr 12;10(4):881. doi: 10.3390/biomedicines10040881

Figure 9.

Figure 9

α-synuclein levels are elevated in the striatum of 23-month-old LRRK2 KO mice. Immunohistochemistry in the striatum of 23-month-old G2019S KI and LRRK2 KO mice in comparison with age-matched WT mice. Optical density (O.D.) of pSer129 α-syn (A) and total α-syn (B) immunostaining was quantified. Data are expressed as mean ± SEM of n = 10 WT mice, n = 8 G2019S KI mice and n = 9 LRRK2 KO mice. Representative images were provided in the upper panels (scale bar =100 µm). Statistical analysis was performed by ANOVA followed by the Tukey test for multiple comparisons. ** p < 0.01 different from WT mice.