Adjusted hazards ratios for death per every 30% decline in eGFR according to varying levels of change in biomarkers of volume overload (a) and biomarkers of hemoconcentration (b).
Cox proportional hazards regression models were used to evaluate the interaction between decline in eGFR and change in surrogate measures of volume overload (BNP, NT-proBNP and weight) and by change in surrogate measures of hemoconcentration (hematocrit, albumin and total protein).
Abbreviations: BNP, b-type natriuretic peptide; eGFR, estimated glomerular filtration rate; NT-proBNP: N-terminal prohormone of b-type natriuretic peptide