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. Author manuscript; available in PMC: 2022 Apr 22.
Published in final edited form as: JACC Heart Fail. 2020 Jun 10;8(7):537–547. doi: 10.1016/j.jchf.2020.03.009

Figure 2.

Figure 2.

Adjusted hazard ratios for death per every 30% eGFR decline within quartiles of change in biomarkers of volume overload (a) and biomarkers of hemoconcentration (b).

Cox proportional hazards regression models examining decline in eGFR within quartiles of change in measures of volume overload (BNP, NT-proBNP and weight) with quartile 1 representing the least decrease and quartile 4 representing the greatest decrease; and within quartiles of change in measures of hemoconcentration (hematocrit, albumin and total protein) with quartile 1 representing the least increase and quartile 4 representing the greatest increase. Interaction testing was performed with decline in eGFR and change in biomarkers both on the continuous scale (represented as p-interaction).

Abbreviations: BNP,b-type natriuretic peptide; eGFR, estimated glomerular filtration rate; NT-proBNP: N-terminal prohormone of b-type natriuretic peptide