Table 2.

Hazard ratio for death and composite outcome based on in-hospital decline in eGFR

	Hazard Ratio Per 30% decline in eGFR
Death
N	3715
N of events	931
Unadjusted HR	0.98 (0.89, 1.09)
Adjusted HR, Model 1*	1.01 (0.91, 1.12)
Adjusted HR, Model 2†	1.19 (1.07, 1.31)
Composite of Cardiovascular Death or Heart Failure hospitalization
N	3715
N of events	1517
Unadjusted HR	0.93 (0.86, 1.01)
Adjusted HR, Model 1*	0.93 (0.86, 1.01)
Adjusted HR, Model 2†	1.09 (1.01, 1.18)

Cox proportional hazards models used to evaluate association between decline in eGFR with death as well as a composite outcome of cardiovascular death and re-hospitalization for heart failure. Log transformation of eGFR by base 10/7 enabled hazard ratios to be assessed per a 3/10 decline, synonymous to a 30% decline.

^*adjusted for age, race, sex, BMI, randomization arm, use of ACEI/ARB, use of aldosterone antagonist

^†adjusted for all of the above as well as baseline eGFR

Abbreviations: BMI, body mass index; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker; BNP,b-type natriuretic peptide; eGFR, estimated glomerular filtration rate;