Table 3.
Hazard ratio for death and composite outcome based on in-hospital changes in biomarkers of volume overload and hemoconcentration
| Measures of Volume Overload | Measures of Hemoconcentration | |||||
|---|---|---|---|---|---|---|
|
BNP Per 50% decline |
NT-proBNP Per 50% decline |
Weight Per every 3 kg decrease |
Hematocrit Per every 3% increase |
Albumin Per every 1 g/dl increase |
Total protein Per every 1 g/dl increase |
|
| Death | ||||||
| N | 2463 | 1274 | 3862 | 3293 | 3618 | 3718 |
| N of events | 490 | 449 | 951 | 808 | 906 | 933 |
| Unadjusted HR | 0.87 (0.81, 0.94) |
0.68 (0.61, 0.76) |
1.00 (0.95, 1.06) |
0.90 (0.85, 0.95) |
0.77 (0.64, 0.93) |
0.88 (0.79, 0.98) |
| Adjusted HR* | 0.78 (0.72, 0.84) |
0.64 (0.57, 0.71) |
1.06 (1.00, 1.13) |
0.89 (0.84, 0.95) |
0.63 (0.52, 0.77) |
0.86 (0.76, 0.96) |
| Composite of CV Death or HF hospitalization | ||||||
| N | 2463 | 1274 | 3862 | 3293 | 3618 | 3718 |
| N of events | 871 | 685 | 1564 | 1318 | 1472 | 1518 |
| Unadjusted HR | 0.89 (0.84, 0.94) |
0.80 (0.74, 0.87 |
0.98 (0.93, 1.02) |
0.93 (0.89, 0.97) |
0.78 (0.68, 0.90) |
0.86 (0.80, 0.94) |
| Adjusted HR* | 0.82 (0.77, 0.87) |
0.76 (0.70, 0.83) |
0.99 (0.94, 1.04) |
0.90 (0.86, 0.94) |
0.68 (0.59, 0.80) |
0.81 (0.74, 0.89) |
Cox proportional hazards models used to evaluate association between decline in biomarkers with death as well as a composite outcome of cardiovascular death and re-hospitalization for heart failure. BNP and NT-proBNP were transformed by log-base 2.
adjusted for age, race, sex, BMI, randomization arm, use of ACEI/ARB, use of aldosterone antagonist and baseline eGFR. Baseline biomarker level was also included as an adjustment variable (ie for change in BNP with outcomes, model included baseline BNP).
Abbreviations: BMI, body mass index; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker; BNP,b-type natriuretic peptide; eGFR, estimated glomerular filtration rate; NT-proBNP: N-terminal prohormone of b-type natriuretic peptide