Table 2.

Results of statistical analysis of dependent variables.

Source	R1		R2
	F-Value	p-Value	F-Value	p-Value
Model	144.14	<0.0001 *	71.67	<0.0001 *
X1	1152.04	<0.0001 *	593.17	<0.0001 *
X2	0.0111	0.9201	0.2627	0.6301
X3	18.68	0.0076 *	5.58	0.0646 *
X1X2	88.20	0.0002 *	24.48	0.0043 *
X2X3	1.09	0.3445	0.6713	0.4499
X3X1	4.36	0.0912	0.1946	0.6775
X12	29.62	0.0028 *	6.09	0.0567
X22	1.01	0.3621	7.34	0.0423 *
X32	4.62	0.0844	10.40	0.0233 *
Lack of Fit	2.01	0.3490	1.32	0.4580
R2 analysis
R²	0.9962		0.9923
Adjusted R²	0.9892		0.9785
Predicted R2	0.9517		0.9124
Adequate Precision	40.8966		27.1516
Model
Remark	Quadratic		Quadratic

X₁: oil concentration (mg); X₂: Tween 80 concentration (mg); X₃: Transcutol^® P; R₁: particle size (nm); R₂: in vitro release (%); *: significant.