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BBD data presenting the independent variables with their levels of variation and the examined dependent responses.
| Independent Variable | Symbol | Level of Variation | ||
|---|---|---|---|---|
| Lowest (−1) |
Central (0) |
Highest (1) |
||
| Oil Concentration (g) | A | 1.5 | 2.0 | 2.5 |
| Tween 80 (g) | B | 0.5 | 1.0 | 1.5 |
| Transcutol® P (g) | C | 1.0 | 1.5 | 2.0 |
| Dependent Variable | Symbol | Constraints | ||
| Particle Size (nm) | R1 | Minimize | ||
| In vitro release (%) | R2 | Maximize | ||
