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. 2022 Mar 24;10(4):757. doi: 10.3390/biomedicines10040757

Figure 7.

Figure 7

Distribution of differentially expressed genes comparing Lipid A and TNF treatments of p65-DsRedxp/IκBα-eGFP BMDMs. Venn diagram illustrating the distribution of differentially expressed genes common to Lipid A-stimulated and TNF-stimulated BMDMs (100 ng/mL Lipid A or TNF 30 ng/mL for 1, 3, and 6 h; n = 3 mice per treatment group). Total RNA was isolated, RNA sequencing was performed, followed by informatics analysis. All genes included were identified as being significantly changed in expression (p < 0.05, corrected for multiple testing using the Benjamini and Hochberg method, and based on log2 fold changes ≥1.5 and ≤−1.5) compared to treated wild-type control mice. Weighted Venn diagram constructed using Biovenn (www.biovenn.nl (accessed on 14 March 2022)) [46] and table using Venn diagram software from Ghent University, freely available at http://bioinformatics.psb.ugent.be/webtools/Venn/ (accessed on 28 January 2022). NFκB target genes identified from database searches are indicated in bold.