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A549 cell invasion in the 3-D micro-chamber of the in vitro model. A 3-D images of cells cultured in the micro-chamber within collagen on Day 1, Day 5, Day 10, and Day 14. The first two columns are in front view and tilted view, respectively. The third column shows cells channel only. Scale bar is 50 μm. B The number of cells invaded out of the micro-chambers on Day 1 to Day 14. C The farthest distance that cells invade out of the micro-chambers on Day 1 to Day 14
