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. 2022 Apr 21;20:182. doi: 10.1186/s12967-022-03387-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig.2 — Identification and characterization of Immune cell subtypes in SIMC and PBMC. a the proportions of immune cells calculated by CIBERSORT, N: controls, P: pemphigus patients. b Barplot of CIBERSORT scores of SIMC in pemphigus and control skin samples. c the heatmap of deferentially expressed chemokine and chemokine receptor in SIMC between pemphigus patients and healthy controls. d Correlation heatmap of different types of immune cells. eImmunohistochemistry staining of CD56 in skin, CD56: NK cell marker. f GSEA enrichment plots of GSE37532, and GSE24574. Normalized enrichment score (NES) indicated the analysis results across gene sets. g GSEA analysis result of SIMC database