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. 2022 Mar 28;10(4):788. doi: 10.3390/biomedicines10040788

Figure 1.

Figure 1

Characterization of PBMC-derived iPSCs from the LHON patient and his family members. (A) the family pedigree chart of the enrolled LHON patient; (B) schematic illustrations of the generation of RGCs from the enrolled LHON patient and his family members; (C) upper: Bright-field images of PBMC-derived iPSCs; lower: Alkaline phosphatase staining revealed the typical pluripotency property of iPSCs. Scale bar: 100 μM (×20). Immunofluorescence staining showed high expression of stemness marker Oct-4, Nanog, and Tra-1-60 in (D) the normal subject-derived iPSCs; (E) carrier-derived iPSCs; and (F) LHON patient-derived iPSCs.