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. 2022 Apr 7;14(4):813. doi: 10.3390/pharmaceutics14040813

Figure 7.

Figure 7

Targeted siRNA delivery by functionalizing the micelle surface with an anti-stem-cell antigen-1 antibody fragment (Fab’) for pulmonary fibrosis therapy [62]. (A) Schematic diagram of the siRNA-loaded polymeric micelles targeting lung mesenchymal stem cells. (B,C) Biodistribution of the delivered micelles. (D) The biodistribution of intravenously administrated micelle–siRNA and anti-Sca1 Fab′-conjugated Micelle-siRNA in organs and (E) images of the organs of a mouse administrated with Fab′–Micelle–siRNA.