Table 1.

Publications on non-viral gene vectors for pulmonary fibrosis.

Vector	Composition	Target Gene	Nucleotide	Expression	Species	Route	Model	Year	Ref.
Liposomes	DOTMA, DOPE	SOD2	plasmid	Up	mice	i.t.	bleomycin	1999	[48]
Polycations	MAA-PEI	HGF	plasmid	Up	mice	i.v.	bleomycin	2005	[49]
Liposomes	DharmaFECT™ 1	SPARC	siRNA	down	mice	i.t.	radiation	2010	[50]
Polycation	PEI	psTNFR-I	plasmid	Up	mice	i.m.	bleomycin	2011	[51]
Polycations	PMAPEG, PDMAEMA	CTGF	siRNA	down	mice	i.t.	bleomycin	2013	[52]
Polycations	DODMA, DSPC, PEG	AR or CTGF	siRNA	down	mice	i.t.	bleomycin	2016	[53]
Liposomes	vitamin A, DC-6-14	HSP47	siRNA	down	rats	i.t.	bleomycin	2017	[54]
Liposomes	NLCs-PGE2	MMP3, CCL12, HIF1A	siRNA	down	mice	i.t.	bleomycin	2017	[55]
Peptides	CADY peptide	SPARC, CCR2, SMAD3	siRNA	down	mice	i.p.	bleomycin	2018	[56]
Polycations	PEI-C22	PAI-1	siRNA	down	mice	i.t.	bleomycin	2019	[57]
Polycations	F-PAMD	PAI-1	siRNA	down	mice	i.t.	bleomycin	2019	[58]
Liposomes	C12-200, mPEG-DMG	MBD2	siRNA	down	mice	i.t.	bleomycin	2021	[59]
Liposomes	C12-200, mPEG-DMG	SART1	siRNA	down	mice	i.t.	bleomycin	2021	[60]
Liposomes	C12-200, mPEG-DMG	SRPX2	siRNA	down	mice	i.t.	bleomycin	2021	[61]
Polycations	PEI-g-PEG-Mal	RUNX1 or Gli1	siRNA	down	mice	i.v.	bleomycin	2021	[62]
Liposomes	C12-200, mPEG-DMG	ACP5	siRNA	down	mice	i.t.	bleomycin	2022	[63]
Polycations	PFC nanoemulsions	STAT3	siRNA	down	mice	i.t.	bleomycin	2022	[64]