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. 2022 Apr 15;23(8):4405. doi: 10.3390/ijms23084405

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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AMP-activated protein kinase (AMPK) inhibitor Compound C protects against tert-butyl hydroperoxide (tBHP)-induced cytotoxicity in immortalized Fischer rat Schwann cells 1 (IFRS1). Treatment with tBHP for 3 h decreased survival rate in IFRS1 cells as measured by MTT assay whereas pretreatment with 5 μM Compound C or 10 μM DHA for 12 h significantly protected against tBHP-induced cytotoxicity. Each value represents the mean ± S.E. of six experiments. **: p < 0.01 compared with tBHP(-); ^##: p < 0.01 compared with tBHP(+).