Table 1.
Demographics, Anthropometrics and Platelet Indices in Study Participants.
| Non-Pregnant (n = 4) (NP) | Healthy Pregnant (n = 5) (PC) | Gestational Hypertension (n = 4) (GH) | Preeclamptic Pregnancy (n = 4) (PE) | |
|---|---|---|---|---|
| Demographics | ||||
| Age (years) | 35.0 ± 6.5 | 32.0 ± 7.1 | 35.0 ± 5.9 | 32.0 ± 6.1 |
| Gestational Age (days) | 275.4 ± 4.5 | 250.8 ± 26.5 | 219.6 ± 39.7 | |
| Height (cm) | 162.0 ± 3.7 | 164.4 ± 2.8 | 162 ± 4.8 | 161.3 ± 9.8 |
| Weight (kg) | 55.8 ± 3.8 | 73.4 ± 9.3 | 84.2 ± 6.3 | 77.4 ± 10.3 |
| BMI (kg/m2) | 21.2 ± 1.6 | 27.9 ± 3.4 | 32.2 ± 4.2 | 29.9 ± 4.7 |
| Urine Protein (g/L) | Not Collected | Not Collected | 0.11 ± 0.04 | 0.60 ± 0.85 |
| sBP (mmHg) * | 105 ± 5 | 112 ± 11 | 143 ± 2 | 149 ± 10 |
| dBP (mmHg) * | 5 ± 4 | 67 ± 9 | 85 ± 7 | 90 ± 3 |
| Hemoglobin levels (g/L) | 133.3 ± 12.0 | 133.2 ± 7.3 | 120.2 ± 6.2 | 123.4 ± 11.1 |
| Positive GDM Screen ** | N/A | 0 | 0 | 0 |
| Platelet Indices | ||||
| Platelet count (109/L) | 270.3 ± 63.6 | 186.0 ± 44.6 | 206.8 ± 33.0 | 252.0 ± 65.9 |
| Mean Platelet Volume (fL) | 10.0 ± 0.8 | 9.1 ± 4.1 | 12.2 ± 0.9 | 11.7 ± 0.7 |
| Immature Platelet Fraction (%) | 2.4 ± 1.2 | 5.0 ± 3.0 | 9.5 ± 3.5 | 7.8 ± 3.1 |
Measurement of variables was at the time of sample collection. Data is presented as mean ± standard deviation. Inclusion Criteria: (1) Healthy non-pregnant females; (2) healthy gravid females presenting between 24 and 42 weeks gestational age (GA); (3) females with gestational hypertension * presenting between 24 and 42 weeks GA; (4) females with preeclampsia * presenting between 24 and 42 weeks GA.* Blood pressure (BP) cutoffs for hypertensive disorders of pregnancy: systolic blood pressure (sBP) ≥ 140 mmHg and/or diastolic blood pressure (dBP) ≥ 90 mmHg defined according to the Society of Obstetricians and Gynecologists of Canada guideline by Magee et al. (2014) (1) Exclusion Criteria: Females, (1) with significant pre-existing cardiovascular, respiratory, neurological, gastrointestinal, endocrine, or hematologic co-morbidities; (2) with pre-existing thrombophilia or coagulation defects; (3) receiving DVT prophylaxis.* Defined according to the Society of Obstetricians and Gynecologists of Canada guideline by Magee et al. (2014) [1]. ** GDM was determined by standard 50 g oral glucose challenge ±75 g oral glucose challenge between 24- and 28-weeks gestational age as per the Society of Obstetricians and Gynecologists of Canada guidelines by Berger et al. (2019) [38]. BMI: Body Mass Index; GDM: Gestational Diabetes Mellitus. The normal range for platelet count in women in Alberta, Canada as determined from provincial clinical records is 150–400 × 109/L.