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. 2022 Apr 11;14(4):789. doi: 10.3390/v14040789

Figure 4.

Figure 4

Network graph demonstrating the relatedness of astronaut and other HSV-1 genomes. The two astronaut-derived HSV-1 genomes (orange) clustered nearest to HSV-1 genomes from China (CR-38) and Russia (L2). This graph-based SplitsTree network was generated from an alignment of the astronaut-derived HSV-1 genomes with 51 HSV-1 genomes that encompass the global genetic diversity of this virus. The Φ statistical test in SplitsTree4 found statistically significant evidence for recombination (p = 0.0), as expected based on prior analyses of HSV-1 phylogenies. The overall geographical origins of the prior HSV-1 genomes are European and North American (red); European, North American, Asian (blue), and African (green). The scale bar represents 0.1% nucleotide divergence. Supplementary Table S1 includes the names, accessions, and geographic origins of each strain.